Hu & Zhang Lab
The State Key Laboratory of Biotherapy Si-Chuan University

Watch the cancer metastasis

Most cancer cells release heterogeneous populations of extracellular vesicles (EVs) containing proteins, lipids, and nucleic acids. In vitro experiments showed that EV uptake can lead to transfer of functional mRNA and altered cellular behavior. However, similar in vivo experiments remain challenging because cells that take up EVs cannot be discriminated from non-EV-receiving cells.  

Used the Cre-LoxP system, Zomer et al was able to directly identify tumor cells that take up EVs in vivo.  They show that EVs released by malignant tumor cells are taken up by less malignant tumor cells located within the same and within distant tumors and that these EVs carry mRNAs involved in migration and metastasis. By intravital imaging, they observed that the less malignant tumor cells that take up EVs display enhanced migratory behavior and metastatic capacity.  So, they postulate that tumor cells locally and systemically share molecules carried by EVs in vivo and that this affects cellular behavior.

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